2 edition of International Symposium on DNA Repair and Chromosome Aberrations, December 22-24, 1983 found in the catalog.
International Symposium on DNA Repair and Chromosome Aberrations, December 22-24, 1983
International Symposium on DNA Repair and Chromosome Aberrations (1983 VaМ„raМ„nasi, Uttar Pradesh, India)
|LC Classifications||IN PROCESS|
|The Physical Object|
|Pagination||32 leaves ;|
|Number of Pages||32|
|LC Control Number||84905571|
Heredity - Heredity - Chromosomal aberrations: The chromosome set of a species remains relatively stable over long periods of time. However, within populations there can be found abnormalities involving the structure or number of chromosomes. These alterations arise spontaneously from errors in the normal processes of the cell. Their consequences are usually deleterious, giving rise to. DNA breaks and chromosomal aberrations arise when replication meets base excision repair. Ensminger M(1), Iloff L(1), Ebel C(1), Nikolova T(2), Kaina B(3), Lӧbrich M(1). Author information: (1)Radiation Biology and DNA Repair, Darmstadt University of Technology, Darmstadt, Germany.
Lichter, P, Jauch, A., Cremer, T, and Ward, D C () Detection of Down syndrome by in situ hybridization with chromosome 21 specific DNA probes, in Molecular Genetics of Chromosome 21 and Down Syndrome (Patterson, D., ed) Liss, New York, pp 69–78 Google Scholar. Induction and Repair of DNA Strand Breaks in CHO-cells Irradiated in Various Phases of the Cycle. (d + T) Neutron-induced Chromosome Aberrations in Human Lymphocytes Irradiated in a Man Phantom. M. Bauchinger, H. Kühn, J. Dresp, E. Schmid & S. Streng. Baxendale Memorial Symposium, 23–24 June D. SCOTT. Page:
The theme of the Symposium–DNA and Chromosomes–goes back 52 years to the Symposium on Genes and Chromosomes: Structure and Organization, although in DNA hardly was mentioned. Then, before Avery, Macleod and McCarty, it was thought of, if at all, as a structural component of chromosomes and nothing to do with their role in heredity. In this lecture I discuss DNA, chromosomes and genomes. In the lecture of chapter 1 from alberts I discussed DNA itself. I followed the order of the book The cell from Alberts, chapter 4.
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Author(s): International Symposium on DNA Repair and Chromosome Aberrations,( Banaras Hindu University) Title(s): Programme & abstracts/ International Symposium on DNA Repair and Chromosome Aberrations, DecemberCountry of Publication: India Publisher: Varanasi, India: Dept.
of Zoology, Banaras Hindu University, [?]. Research on DNA and chromosome aberrations focuses on cancer genetics and epigenetics. Topics include regulation of gene expression; DNA damage from exposure to chemical, physical, and endogenous agents; mechanisms of DNA damage signaling and DNA repair; and genomic instability and related molecular, cytogenetic, and chromosomal effects during tumor formation and progression to.
Introduction. Most chemicals exert their genotoxic effects when the primary DNA damage interferes with replication (Evans and Scott, ).This is true for chemicals inducing bulky lesions or DNA cross-links, for simple methylating agents, and also for UV light (Bender et al., ; Kaina, ).Methylating agents are powerful genotoxicants that induce chromosomal breaks and Cited by: From DNA damage to chromosome aberrations: Joining the break at the 10th International Symposium on Chromosomal Aberrations (this issue).
Windhofer, W. Wu, J. Guan, G. Terzoudi, G. PanteliasMechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet. Genome Res., (), pp. Cited by: The 5th International Symposium on Chromosomal This can give clues for the observed heterogeneity among the chromosomes for involvement aberrations.
The type of DNA repair involved in the formation of aberrations can be resolved by studies using mutant cell lines with very defined defect in repair as well as transgenic mice (cell lines. However, the contribution of different molecular DNA repair mechanisms (e.g., alternative end-joining pathways) and their impact on the kinetics of aberration formation is still unclear, as is the definition of “complex” radiogenic damaged sites 1983 book in either the chemical or spatial sense – which ostensibly lead to chromosome rearrangements.
Long before the importance of DNA repair was recognized by biochemists, cytogeneticists were engaged in studies on the relationship between repair of chromosome damage and chromosome aberrations. Studies by Karl Sax in the s on radiation dose fractionation and dose-rate effects clearly pointed out the role of repair on the yield of.
, human chromosome 1 contains a DNA molecule of cm length which in interphase is packed in a ﬁbrillar structure of m. In metaphase, chromo-some 1 is about 10 m long.
These packaging prob-lems are mainly solved by proteins of various types [20,21]. Due to their enormous dimensions, DNA molecules in chromosomes are permanent targets of.
Abstract. Recent work in Medical Cytogenetics has demonstrated not only the close association between specific chromosome alterations and specific forms of cancer (81, 22, 34), but has also shown that oncogenes can be found to be involved in these specific chromosome alterations (17, 25, 2, 15).
Main chromosome aberrations among chromosomal studies at a third level pediatric Mexican hospital in 19 years period of time Aparicio-Rodríguez J. M.1,13, Hurtado-Hernández M. L.2, Marroquín-García I.2, Rojas-Rivera G. Chromosome aberrations are departures from the normal set of chromosomes either for an individual or from a species.
They can refer to changes in the number of sets of chromosomes (ploidy), changes in the number of individual chromosomes (somy), or changes in appearance of individual chromosomes through mutation-induced rearrangements. Survival, frequency of chromosome aberrations, DNA content of nuclei, seed fertility and frequency of mutations in the second and third generations were used as indices of radiosensitivity.
Survival was better in 4x barley in comparison with the diploid in X-ray treatments, while an increase in radiation resistance with an increase in.
The resulting chromosome aberrations were detected in first-division cells using a series of FISH assays in which either one or two chromosomes (nos. 1, 2, 4, 5, 7 and 13) and all centromeres were. Common polymorphisms in DNA repair genes may alter protein function and an individual’s capacity to repair damaged DNA.
A deficient repair capacity may lead to genetic instability and ultimately to cancer initiation. In this study, we found significant influences of XRCC1 (rs) and PARP1 (rs) on the effect of exposure to FA.
In the mids, a mild Augustinian friar named Gregor Mendel crossbred pea plants and pioneered the beginnings of understanding inherited traits.
Genetics has come a long way since then. Neither Mendel nor Charles Darwin knew anything about the incredible molecule of life, DNA. Today, papers are published daily in science journals describing new discoveries of DNA’s role as a regulator and.
FISH for chromosome 9 is targeted at a specific and frequent genetic aberration in bladder cancer. The combination of FISH on chromosome 9 and DNA cytometry provides a significant increase in sensitivity for all grades of bladder cancer over either test alone and may provide useful prognostic information.
In the present study, we have further evaluated a nested group of 79 patients and 69 matched controls, and observed that increased chromosome aberrations (CAs) were associated with variant DNA-repair genotypes among both the patient and the control groups, with a significant increase for individuals having the XPD Lys/Gln + Gln/Gln genotypes (P.
Results. The total chromosome aberration rates (%) and micronuclear rates (%) of the exposure group were significantly higher than in the control group (P = ).The percentage of DNA in the comet tail, tail moment, and Olive tail moment detected by comet assay showed that there was a significant difference in DNA damage in the exposure group (P = ).
Proceeding of the 10 th International Symposium of Metal DNA repair, and epigenetic programming. Decreases in the repair processes and increases in the frequency of chromosome aberrations.
To enable scoring of different chromosome aberration types resulting from improper joining of DNA fragments, the repair module has been complemented by tracking the chromosome origin of the.Related Publications: Human DNA Repair Genes. Wood RD, Mitchell M, Sgouros JG, Lindahl T, Science() Abstract Human DNA Repair Genes, Wood RD, Mitchell M, Lindahl T, Mutation Res.() Abstract DNA Repair and Mutagenesis, 2nd edition (ASM Press, Washington, DC).Among them was the first book on genetics in the USSR (after the nearly year ban on genetics established in the USSR by Joseph Stalin) "Arithmetic of Heredity" (, translated into Estonian in ), "Repair Systems of Cells" (, translated into Vietnamese in ), "Contemporary Problems of Biology" (), "Molecules of Living Cells.